ترجمة 19
اقتباس
Menon et al. studied the formation of pellets by
fluid-bed granulation using this design.[8] The five factors
investigated were (X1), the binder concentration;
(X2), the method of introducing it (dry or solution);
(X3), the atomization pressure; (X4), the spray rate;
and (X5), the inlet temperature. Particle sizes of the
resulting particles are shown in Table 3.
درس مينون وزملاؤه تشكيل الكريات باستخدام تقنية التحثير بالسرير الهوائي fluid-bed granulation.[8] وقد تمت دراسة خمسة عوامل مؤثّرة هي (X1) تركيز العامل الرابط binder و(X2) طريقة إدخاله (بشكل مسحوق جاف أو بشكل محلول) و(X3) ضغط الإرذاذ و(X4) سرعة الإرذاذ و (X5) حرارة الحجرة (المدخل) inlet. ويبين الجدول -3- أحجام الجزيئات (الجسيمات) الناتجة عن هذه التقنية.
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21 - (ستترجمها نسرين)
Information that Can Be Obtained
The significant main effects are identified and also quantified.
Thus, increasing the spray rate over the range
studied will give an increase in the log(particle size) of
twice 0.24, representing a more than threefold increase.
However, it can be seen that there is an interaction with
the binder concentration; that is, the effect of spray rate
depends on the amount of binder in the formulation.
The effects of increasing spray rate are shown in Fig. 3
for both high and low levels of binder; the effect of spray
rate is much greater at high levels of binder.
22- (ستترجمها نسرين)
However, the effect of binder also interacts with two
other factors, the atomization pressure and the inlet
temperature. Thus, the individual variables cannot be
considered separately.
Note also that there is a great deal of information
often hidden in large designs (16 or more experiments),
and, in particular, indications on factors affecting the
robustness of a process may sometimes be extracted
(see the last section).
23-
Use of Center Points
In both screening and factor-influence studies in which
the factor is quantitative, it is tempting to interpolate
between the upper and lower limits. This is useful if
only to find a more restricted zone for further
study. However, in the case of a screening study, the
limits studied are often so wide that it would be most
unlikely for the estimated model to be accurate enough
for prediction, and there is also likely to be curvature
of the response surface over the experimental domain.
Such attempts are less risky for the more detailed factorial
studies, but even then, they should be used with
caution.
24-
Adding center points (experiments at the center of
the domain, coded co-ordinates 0, 0, . . . 0 is useful for
factorial and screening experiments), even though they
do not enter into the calculation of the model equation
because:
1. They are often a priori at or near the most interesting
conditions;
2. They allow identification of curvature in the
responses (by comparing calculated with measured
responses);
3. If they are replicated, the experimental reproducibility
may be assessed; and
4. They may allow extension of the experiment
at a subsequent stage to a central composite
design for modeling of response surfaces (shown
in the following sections).
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ترجمة قسم : Optimization Methods
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